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Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.
Domingo-Relloso, Arce; Makhani, Kiran; Riffo-Campos, Angela L; Tellez-Plaza, Maria; Klein, Kathleen Oros; Subedi, Pooja; Zhao, Jinying; Moon, Katherine A; Bozack, Anne K; Haack, Karin; Goessler, Walter; Umans, Jason G; Best, Lyle G; Zhang, Ying; Herreros-Martinez, Miguel; Glabonjat, Ronald A; Schilling, Kathrin; Galvez-Fernandez, Marta; Kent, Jack W; Sanchez, Tiffany R; Taylor, Kent D; Johnson, W Craig; Durda, Peter; Tracy, Russell P; Rotter, Jerome I; Rich, Stephen S; Van Den Berg, David; Kasela, Silva; Lappalainen, Tuuli; Vasan, Ramachandran S; Joehanes, Roby; Howard, Barbara V; Levy, Daniel; Lohman, Kurt; Liu, Yongmei; Fallin, M Daniele; Cole, Shelley A; Mann, Koren K; Navas-Acien, Ana.
  • Domingo-Relloso A; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
  • Makhani K; Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
  • Riffo-Campos AL; Department of Statistics and Operations Research (A.D.-R.), University of Valencia, Spain.
  • Tellez-Plaza M; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.).
  • Klein KO; Department of Computer Science, ETSE (A.L.R.-C.), University of Valencia, Spain.
  • Subedi P; Millennium Nucleus on Sociomedicine (SocioMed) and Vicerrectoría Académica, Universidad de La Frontera, Temuco, Chile (A.L.R.-C.).
  • Zhao J; Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
  • Moon KA; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada (K.M., K.O.K., K.K.M.).
  • Bozack AK; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.).
  • Haack K; Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville (P.S., J.Z.).
  • Goessler W; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.A.M.).
  • Umans JG; Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley (A.K.B.).
  • Best LG; Population Health Program, Texas Biomedical Research Institute, San Antonio' TX (K.H., J.W.K., S.A.C.).
  • Zhang Y; Institute of Chemistry - Analytical Chemistry for Health and Environment, University of Graz, Austria (W.G.).
  • Herreros-Martinez M; MedStar Health Research Institute, Hyattsville, MD. Now with Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.W.H.).
  • Glabonjat RA; Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC (J.G.U., B.V.H.).
  • Schilling K; Missouri Breaks Industries and Research, Inc, Eagle Butte, SD (L.G.B.).
  • Galvez-Fernandez M; Department of Biostatistics and Epidemiology, The University of Oklahoma Health Sciences Center (Y.Z.).
  • Kent JW; Bioinformatics Unit, Institute for Biomedical Research INCLIVA, Valencia, Spain (M.H.-M.).
  • Sanchez TR; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
  • Taylor KD; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
  • Johnson WC; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
  • Durda P; Integrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain (A.D.-R., M.T.-P., M.G.-F.).
  • Tracy RP; Population Health Program, Texas Biomedical Research Institute, San Antonio' TX (K.H., J.W.K., S.A.C.).
  • Rotter JI; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY (A.D.-R., R.A.G., K.S., M.G.-F., T.R.S., A.N.-A.).
  • Rich SS; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (K.D.T., J.I.R.).
  • Van Den Berg D; Department of Biostatistics, University of Washington, Seattle (W.C.J.).
  • Kasela S; Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT (P.D., R.P.T.).
  • Lappalainen T; Department of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT (P.D., R.P.T.).
  • Vasan RS; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (K.D.T., J.I.R.).
  • Joehanes R; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA (S.S.R.).
  • Howard BV; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles' CA (D.V.D.B.).
  • Levy D; New York Genome Center (S.K., T.L.).
  • Lohman K; Department of Systems Biology, Columbia University' NY (S.K., T.L.).
  • Liu Y; New York Genome Center (S.K., T.L.).
  • Fallin MD; Department of Systems Biology, Columbia University' NY (S.K., T.L.).
  • Cole SA; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA (R.S.V.).
  • Mann KK; Sections of Preventive Medicine and Epidemiology and Cardiovascular Medicine, Department of Medicine, Department of Epidemiology, Boston University Schools of Medicine and Public Health, MA (R.S.V.).
  • Navas-Acien A; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.J., D.L.).
Circ Res ; 131(2): e51-e69, 2022 07 08.
Article en En | MEDLINE | ID: mdl-35658476
ABSTRACT

BACKGROUND:

Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD.

METHODS:

Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Strong Heart Study, a prospective cohort of American Indians. Urinary arsenic species were measured using high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. We identified DMPs that are potential mediators between arsenic and CVD. In a cross-species analysis, we compared those DMPs with differential liver DNA methylation following early-life arsenic exposure in the apoE knockout (apoE-/-) mouse model of atherosclerosis.

RESULTS:

A total of 20 and 13 DMPs were potential mediators for CVD incidence and mortality, respectively, several of them annotated to genes related to diabetes. Eleven of these DMPs were similarly associated with incident CVD in 3 diverse prospective cohorts (Framingham Heart Study, Women's Health Initiative, and Multi-Ethnic Study of Atherosclerosis). In the mouse model, differentially methylated regions in 20 of those genes and DMPs in 10 genes were associated with arsenic.

CONCLUSIONS:

Differential DNA methylation might be part of the biological link between arsenic and CVD. The gene functions suggest that diabetes might represent a relevant mechanism for arsenic-related cardiovascular risk in populations with a high burden of diabetes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsénico / Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Arsénico / Enfermedades Cardiovasculares / Aterosclerosis Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article