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Pharmacokinetics, mass balance, and metabolism of [14C]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension.
He, Yi-Fei; Liu, Yin; Yu, Jing-Hua; Cheng, Huan; Odilov, Abdullajon; Yang, Fei-Pu; Tian, Guang-Hui; Yao, Xiu-Mei; Duan, Hua-Qing; Yu, Cheng-Yin; Yu, Chen; Liu, Yan-Mei; Liu, Gang-Yi; Shen, Jing-Shan; Wang, Zhen; Diao, Xing-Xing.
  • He YF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Liu Y; University of the Chinese Academy of Sciences, Beijing, 100049, China.
  • Yu JH; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Cheng H; University of the Chinese Academy of Sciences, Beijing, 100049, China.
  • Odilov A; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Yang FP; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Tian GH; School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Ji-nan, 250355, China.
  • Yao XM; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Duan HQ; University of the Chinese Academy of Sciences, Beijing, 100049, China.
  • Yu CY; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Yu C; Vigonvita Life Sciences Co., Ltd, Suzhou, 215000, China.
  • Liu YM; Vigonvita Life Sciences Co., Ltd, Suzhou, 215000, China.
  • Liu GY; Vigonvita Life Sciences Co., Ltd, Suzhou, 215000, China.
  • Shen JS; Shanghai Xuhui Central Hospital, Shanghai, 200030, China.
  • Wang Z; Shanghai Xuhui Central Hospital, Shanghai, 200030, China.
  • Diao XX; Shanghai Xuhui Central Hospital, Shanghai, 200030, China.
Acta Pharmacol Sin ; 44(1): 221-233, 2023 Jan.
Article en En | MEDLINE | ID: mdl-35676531
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa 5 / Hipertensión Arterial Pulmonar Tipo de estudio: Guideline / Prognostic_studies Límite: Humans / Male Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Fosfodiesterasa 5 / Hipertensión Arterial Pulmonar Tipo de estudio: Guideline / Prognostic_studies Límite: Humans / Male Idioma: En Año: 2023 Tipo del documento: Article