Oxalierpenes A and B, Unusual Indole-Diterpenoid Derivatives with Antiviral Activity from a Marine-Derived Strain of the Fungus Penicillium oxalicum.
J Nat Prod
; 85(7): 1880-1885, 2022 07 22.
Article
en En
| MEDLINE
| ID: mdl-35729787
ABSTRACT
Oxalierpenes A and B (1 and 2), two unusual indole-diterpenoid derivatives, were obtained from the marine-derived fungus Penicillium oxalicum. The absolute configurations of 1 and 2 were elucidated by calculated TDDFT ECD and DP4plus methods. Oxalierpene A (1) represents the first indole-diterpenoid derivative with a five-membered ring of 4-hydroxy-5,5-dimethyldihydrofuran-3-one as a side chain. Oxalierpene B (2) has a unique 6/5/6/5/5/6/6/5/5 ring system. Compounds 1 and 2 showed antiviral activity against the H1N1 virus and respiratory syncytial virus (RSV), with IC50 values ranging from 2.8 to 9.4 µM.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Penicillium
/
Diterpenos
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Subtipo H1N1 del Virus de la Influenza A
Idioma:
En
Año:
2022
Tipo del documento:
Article