New Cladiellin-Type Diterpenoids from the South China Sea Soft Coral Cladiella krempfi: Structures and Molecular Docking Analysis in EGFRs.
Mar Drugs
; 20(6)2022 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-35736185
ABSTRACT
Two new cladiellin-type diterpenoids (1 and 2) and four known related compounds 3-6, were isolated from the South China Sea soft coral Cladiella krempfi. Compound 2 is the third example of cladiellins of an unusual peroxy group in the C-6 position in C. krempfi. The structures and absolute configurations of the new compounds were established by extensive spectroscopic analysis, X-ray diffraction, and/or chemical correlation. In bioassay, all the compounds were evaluated for cytotoxicity and epidermal growth factor receptor (EGFR) inhibitory activity. A molecular docking experiment was conducted to study the structure-activity relationship of cladiellin-type diterpenoids on EGFR inhibitory activity.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antozoos
/
Diterpenos
Límite:
Animals
País como asunto:
Asia
Idioma:
En
Año:
2022
Tipo del documento:
Article