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Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling.
Zhou, Yu-Wei; Sun, Jie; Wang, Ye; Chen, Cai-Ping; Tao, Tao; Ma, Ming; Chen, Xin; Zhang, Xue-Na; Yang, Li-Yuan; Zhang, Zhong-Liang; Li, Ye-Qiong; Jiang, Zhi-Hui; Qiu, Tian-Tian; Wang, Han; Pan, Yang; Zhang, Jian; Chen, Hua-Qun; Wang, Pei; Zhu, Min-Sheng.
  • Zhou YW; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Sun J; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Wang Y; Collage of Life Science, Nanjing Normal University, Nanjing, 210023, China.
  • Chen CP; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Tao T; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Ma M; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Chen X; Department of Drug Development, Shanghai KE Pharmaceutical Ltd, Co., Shanghai, 200003, China.
  • Zhang XN; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Yang LY; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Zhang ZL; Department of Drug Development, Shanghai KE Pharmaceutical Ltd, Co., Shanghai, 200003, China.
  • Li YQ; Department of Drug Development, Shanghai KE Pharmaceutical Ltd, Co., Shanghai, 200003, China.
  • Jiang ZH; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Qiu TT; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Wang H; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Pan Y; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
  • Zhang J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
  • Chen HQ; College of of Life Science, Yunnan University, Yunnan, 650091, China.
  • Wang P; Collage of Life Science, Nanjing Normal University, Nanjing, 210023, China.
  • Zhu MS; State Key Laboratory of Pharmaceutical Biotechnology, Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, 210008, China.
Proc Natl Acad Sci U S A ; 119(26): e2121513119, 2022 06 28.
Article en En | MEDLINE | ID: mdl-35737832
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Activación Transcripcional / Enfermedad Pulmonar Obstructiva Crónica / Receptores Acoplados a Proteínas G / Músculo Liso Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Asma / Activación Transcripcional / Enfermedad Pulmonar Obstructiva Crónica / Receptores Acoplados a Proteínas G / Músculo Liso Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article