Correlation among clinical, functional and morphological indexes of the respiratory system in non-cystic fibrosis bronchiectasis patients.
PLoS One
; 17(7): e0269897, 2022.
Article
en En
| MEDLINE
| ID: mdl-35793286
ABSTRACT
BACKGROUND:
Non-cystic fibrosis bronchiectasis (NCFB) is a heterogeneous disease, which assessment and severity can't be defined by one particular instrument but using a multidimensional score. Thus, in additional to traditional methods, alternative tools have been developed to assist these patients' evaluation.OBJECTIVE:
To correlate functional and morphological indexes with severity and dyspnea in NCFB patients, focusing on the correlation between the impulse oscillometry system (IOS) and the quantitative analysis of computed tomography (CT).METHODS:
Clinically stable NCFB patients, between 18 and 80 years old were submitted to clinical, functional and morphological evaluations assessed by Bronchiectasis Severity Index (BSI) and Medical Research Council (MRC) scale; spirometry and IOS; and subjective and quantitative Chest CT scans analysis, respectively.RESULTS:
This study included 38 patients. The best correlations obtained between functional and morphological airway indexes were resistance at 5 Hz-R5 and the normalized thickness of bronchial walls-Pi10 (r = 0.57), and the mean forced expiratory flow (FEF25-75%) and CT score (r = -0.39). BSI as well as MRC showed higher correlations with the quantitative automated analysis of CT (BSI and Pi10 r = 0.41; MRC and Pi10 r = 0.35) than with subjective CT score (BSI and CT score r = 0.41; MRC and CT score r = 0.15); and moderate and weak correlations were obtained on both functional airway indexes (BSI and peripheral airways resistance - R5-R20 r = 0.53; BSI and forced expiratory volume at the first second-FEV1 R = -0,64; MRC and R5-R20 r = 0.42; and MRC and VEF1 r = -0.45).CONCLUSION:
In NCFB patients, compartmentalized methods for assessing the respiratory system (IOS and the automated quantitative CT analysis) have a good correlation with severity and dyspnea.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bronquiectasia
/
Fibrosis Quística
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Humans
/
Middle aged
Idioma:
En
Año:
2022
Tipo del documento:
Article