Systemic calcinosis in a Quarter Horse gelding homozygous for a myosin heavy chain 1 mutation.
J Vet Intern Med
; 36(4): 1543-1549, 2022 Jul.
Article
en En
| MEDLINE
| ID: mdl-35801821
ABSTRACT
CASE DESCRIPTION A 9-year-old Quarter Horse gelding was presented for lethargy, decreased appetite, polyuria and polydipsia (PU/PD), and severe muscle wasting suggestive of immune-mediated myositis. CLINICAL FINDINGS:
The horse displayed lethargy, fever, tachyarrhythmia, inappetence, PU/PD, and severe epaxial and gluteal muscle wasting. Clinicopathologic findings were consistent with previously reported cases of systemic calcinosis in horses, including increased muscle enzyme activity, hyperphosphatemia, increased calcium-phosphorus product, hypoproteinemia, and an inflammatory leukogram. A diagnosis of systemic calcinosis was established by histopathologic evaluation of biopsy specimens from skeletal muscle, lung, and kidney. TREATMENT ANDOUTCOME:
Symptomatic treatment was complemented by IV treatment with sodium thiosulfate to reverse calcium-phosphate precipitation in soft tissue and PO aluminum hydroxide to decrease intestinal phosphorus absorption and serum phosphorus concentration. CLINICAL RELEVANCE This is the first report in the veterinary literature of an antemortem diagnosis of systemic calcinosis in the horse that was successfully treated and had favorable long-term outcome.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Calcinosis
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Enfermedades de los Caballos
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Enfermedades Musculares
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article