The pharmacology of the TMEM16A channel: therapeutic opportunities.
Trends Pharmacol Sci
; 43(9): 712-725, 2022 09.
Article
en En
| MEDLINE
| ID: mdl-35811176
ABSTRACT
The TMEM16A Ca2+-gated Cl- channel is involved in a variety of vital physiological functions and may be targeted pharmacologically for therapeutic benefit in diseases such as hypertension, stroke, and cystic fibrosis (CF). The determination of the TMEM16A structure and high-throughput screening efforts, alongside ex vivo and in vivo animal studies and clinical investigations, are hastening our understanding of the physiology and pharmacology of this channel. Here, we offer a critical analysis of recent developments in TMEM16A pharmacology and reflect on the therapeutic opportunities provided by this target.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Canales de Cloruro
/
Fibrosis Quística
Límite:
Animals
Idioma:
En
Año:
2022
Tipo del documento:
Article