Your browser doesn't support javascript.
loading
[Association of glutamate receptor metabotropic 5 polymorphisms with schizophrenia susceptibility in a Chinese Han population].
Song, M; Liu, Y; Wang, X J; Zhang, L W; Liu, Q; Chen, T F; Su, X; Li, W W; Lyu, L X; Yang, Y F.
  • Song M; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Liu Y; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Wang XJ; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Zhang LW; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Liu Q; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Chen TF; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Su X; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Li WW; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Lyu LX; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
  • Yang YF; Department of Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Henan Mental Hospital, Henan Key Lab of Biological Psychiatry, Xinxiang 453002, China.
Zhonghua Yi Xue Za Zhi ; 102(27): 2108-2114, 2022 Jul 19.
Article en Zh | MEDLINE | ID: mdl-35844113
ABSTRACT

Objectives:

To investigate the association of single nucleotide polymorphisms (SNP) of glutamate receptor metabotropic 5 (GRM5) gene with schizophrenia susceptibility(SZ) in a Chinese Han population.

Methods:

Twenty-two SNPs located in GRM5 gene in 528 paranoid SZ patients and 528 control subjects recruited from northern Henanwere analyzed. The clinical features of 267 first-episode SZ patients were assessed with the Positive and Negative Syndrome Scale (PANSS).

Results:

The SZ group included 264 males and 264 females, aged (27±8) years; the healthy control group had 264 males and 264 females, aged (28±8) years.The differences in the genotypic and allelic frequencies of two SNPs (rs567990 and rs12421343) were statistically significant between the SZ patients and control groups (all P<0.05). The allele frequency of rs504183 was also statistically different between the two groups (P=0.030). When the subjects were stratified by sex, the genotypic and allelic frequencies of rs12421343 in female subjects were statistically different between the SZ patients and control groups. The allele frequencies of SNPs (rs12422021, rs567990, and rs7101540) were also statisticallydifferent between the two groups (all P<0.05). Meanwhile, rs567990 AG+GG carriers had a higher risk for SZ than AA carriers in female subjects(OR=1.946, 95%CI 1.264-2.995). In addition, the patients with different genotypes (GG, AA+AG) of rs12422021 showed statistically significant differences in PANSS total score(84.8±24.4 vs 75.3±18.6), positive (16.2±4.3 vs 14.4±4.2), excitement (12.4±5.1 vs 10.2±4.1) and cognitive impairment factor scores (15.2±6.8 vs 13.3±3.9) (all P<0.05). The patients with AC and the other two genotypes (AA and CC) of rs504183 showed statistically significant differences in PANSS negative factor score(27.4±9.9 vs 24.7±8.4 and 23.4±8.1, both P<0.05).

Conclusion:

The current study provides further evidence that GRM5 is associated with SZ, and suggests a putative sex difference.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esquizofrenia / Receptor del Glutamato Metabotropico 5 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male País como asunto: Asia Idioma: Zh Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esquizofrenia / Receptor del Glutamato Metabotropico 5 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male País como asunto: Asia Idioma: Zh Año: 2022 Tipo del documento: Article