Crystal structure of Ankyrin-G in complex with a fragment of Neurofascin reveals binding mechanisms required for integrity of the axon initial segment.

He, Liping; Jiang, Wenli; Li, Jianchao; Wang, Chao

He, Liping; Jiang, Wenli; Li, Jianchao; Wang, Chao.

He L; Department of Neurology, The First Affiliated Hospital of USTC, Ministry of Education Key Laboratory for Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life S
Jiang W; Department of Neurology, The First Affiliated Hospital of USTC, Ministry of Education Key Laboratory for Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life S
Li J; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, P. R. China. Electronic address: lijch@scut.edu.cn.
Wang C; Department of Neurology, The First Affiliated Hospital of USTC, Ministry of Education Key Laboratory for Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life S

J Biol Chem ; 298(9): 102272, 2022 09.

Article en En | MEDLINE | ID: mdl-35850303

Asunto(s)

Repetición de Anquirina; Ancirinas; Segmento Inicial del Axón; Moléculas de Adhesión Celular; Factores de Crecimiento Nervioso; Animales; Ancirinas/química; Segmento Inicial del Axón/química; Sitios de Unión; Moléculas de Adhesión Celular/química; Moléculas de Adhesión Celular/genética; Cristalografía por Rayos X; Ratones; Factores de Crecimiento Nervioso/química; Factores de Crecimiento Nervioso/genética; Molécula L1 de Adhesión de Célula Nerviosa/genética; Molécula L1 de Adhesión de Célula Nerviosa/metabolismo; Dominios Proteicos

Palabras clave

Ankyrin-G; L1 syndrome; L1CAM; Neurofascin; axon initial segment; crystal structure; neuronal polarity

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Moléculas de Adhesión Celular / Ancirinas / Repetición de Anquirina / Segmento Inicial del Axón / Factores de Crecimiento Nervioso Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

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