Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.
Circ Res
; 131(4): e84-e99, 2022 08 05.
Article
en En
| MEDLINE
| ID: mdl-35862024
ABSTRACT
BACKGROUND:
To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations.METHODS:
PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION URL https//www. CLINICALTRIALS gov; Unique identifier NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION URL https//www. CLINICALTRIALS gov; Unique identifier NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation).RESULTS:
We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs 12,13-diHOME, 9,10-diHOME, lysoPC(150), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD.CONCLUSIONS:
We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Cardiovasculares
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Ejercicio Físico
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Inhibidores de Hidroximetilglutaril-CoA Reductasas
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article