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Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.
Hoshi, Rosangela A; Liu, Yanyan; Luttmann-Gibson, Heike; Tiwari, Saumya; Giulianini, Franco; Andres, Allen M; Watrous, Jeramie D; Cook, Nancy R; Costenbader, Karen H; Okereke, Olivia I; Ridker, Paul M; Manson, JoAnn E; Lee, I-Min; Vinayagamoorthy, Manickavasagar; Cheng, Susan; Copeland, Trisha; Jain, Mohit; Chasman, Daniel I; Demler, Olga V; Mora, Samia.
  • Hoshi RA; Center for Lipid Metabolomics, Division of Preventive Medicine, Division of Cardiovascular Medicine (R.A.H., Y.L., H.L.-G., P.M.R., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Liu Y; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Luttmann-Gibson H; Center for Lipid Metabolomics, Division of Preventive Medicine, Division of Cardiovascular Medicine (R.A.H., Y.L., H.L.-G., P.M.R., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Tiwari S; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Giulianini F; Center for Lipid Metabolomics, Division of Preventive Medicine, Division of Cardiovascular Medicine (R.A.H., Y.L., H.L.-G., P.M.R., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Andres AM; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Watrous JD; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.L.-G., O.I.O., J.E.M., I.-M.L., M.J.).
  • Cook NR; Department of Pharmacology, University of California San Diego, La Jolla (S.T., A.M.A., J.D.W.).
  • Costenbader KH; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Okereke OI; Department of Pharmacology, University of California San Diego, La Jolla (S.T., A.M.A., J.D.W.).
  • Ridker PM; Department of Pharmacology, University of California San Diego, La Jolla (S.T., A.M.A., J.D.W.).
  • Manson JE; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Lee IM; Division of Rheumatology, Inflammation and Immunity (K.H.C.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Vinayagamoorthy M; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.L.-G., O.I.O., J.E.M., I.-M.L., M.J.).
  • Cheng S; Department of Psychiatry, Massachusetts General Hospital, Boston (O.I.O.).
  • Copeland T; Center for Lipid Metabolomics, Division of Preventive Medicine, Division of Cardiovascular Medicine (R.A.H., Y.L., H.L.-G., P.M.R., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Jain M; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Chasman DI; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Demler OV; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (H.L.-G., O.I.O., J.E.M., I.-M.L., M.J.).
  • Mora S; Division of Preventive Medicine (R.A.H., Y.L., H.L.-G., F.G., N.R.C., P.M.R., J.E.M., I.-M.L., M.V., T.C., D.I.C., O.V.D., S.M.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Circ Res ; 131(4): e84-e99, 2022 08 05.
Article en En | MEDLINE | ID: mdl-35862024
ABSTRACT

BACKGROUND:

To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations.

METHODS:

PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION URL https//www. CLINICALTRIALS gov; Unique identifier NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION URL https//www. CLINICALTRIALS gov; Unique identifier NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation).

RESULTS:

We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs 12,13-diHOME, 9,10-diHOME, lysoPC(150), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD.

CONCLUSIONS:

We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ejercicio Físico / Inhibidores de Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Ejercicio Físico / Inhibidores de Hidroximetilglutaril-CoA Reductasas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article