Detection of Synergistic Interaction on an Additive Scale Between Two Drugs on Abnormal Elevation of Serum Alanine Aminotransferase Using Machine-Learning Algorithms.

Akimoto, Hayato; Nagashima, Takuya; Minagawa, Kimino; Hayakawa, Takashi; Takahashi, Yasuo; Asai, Satoshi

Akimoto, Hayato; Nagashima, Takuya; Minagawa, Kimino; Hayakawa, Takashi; Takahashi, Yasuo; Asai, Satoshi.

Akimoto H; Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Nagashima T; Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Minagawa K; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Hayakawa T; Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.
Takahashi Y; Division of Genomic Epidemiology and Clinical Trials, Clinical Trials Research Center, Nihon University School of Medicine, Tokyo, Japan.
Asai S; Division of Pharmacology, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan.

Front Pharmacol ; 13: 910205, 2022.

Article en En | MEDLINE | ID: mdl-35873565

Palabras clave

alanine aminotransferase; drug induced liver injury (DILI); drug interaction; liver function; machine-learning (ML) algorithms; relative excess risk due to interaction (RERI); synergistic effect

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article