Cobalt-promoted synthesis of sulfurated oxindoles via radical annulation of N-arylacrylamides with disulfides.
Org Biomol Chem
; 20(32): 6423-6431, 2022 08 17.
Article
en En
| MEDLINE
| ID: mdl-35880643
ABSTRACT
An efficient radical annulation of N-arylacrylamides with disulfides is developed for the synthesis of sulfurated oxindoles. The reaction occurs in a facile manner using CoBr2 as both an initiator and a promoter for the first time and (NH4)2S2O8 as the oxidant. By controlling the CoBr2/(NH4)2S2O8 ratio, a wide range of sulfurated and brominated/sulfurated oxindoles are selectively prepared in good to excellent yields. The present protocol is simple and highly atom economical, and can tolerate a broad range of substrates.
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1
Banco de datos:
MEDLINE
Asunto principal:
Cobalto
/
Disulfuros
Idioma:
En
Año:
2022
Tipo del documento:
Article