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Blood Pressure and Body Composition During First Year of Antiretroviral Therapy in People With HIV Compared With HIV-Uninfected Community Controls.
Kavishe, Bazil Baltazar; Olsen, Mette Frahm; Filteau, Suzanne; Kitilya, Brenda W; Jeremiah, Kidola; Krogh-Madsen, Rikke; Todd, Jim; Friis, Henrik; Faurholt-Jepsen, Daniel; PrayGod, George; Peck, Robert.
  • Kavishe BB; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
  • Olsen MF; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
  • Filteau S; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Kitilya BW; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
  • Jeremiah K; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
  • Krogh-Madsen R; Mwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
  • Todd J; Centre for Physical Activity Research, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Friis H; Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark.
  • Faurholt-Jepsen D; Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
  • PrayGod G; Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  • Peck R; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Am J Hypertens ; 35(11): 929-937, 2022 11 02.
Article en En | MEDLINE | ID: mdl-35881168
ABSTRACT

BACKGROUND:

Body composition changes may explain the rapid increase in blood pressure (BP) in people with HIV (PWH) during the first year of antiretroviral therapy.

METHODS:

We analyzed data from a cohort of PWH and HIV-uninfected adults from the same communities in Mwanza, Tanzania. Blood pressure (BP, mm Hg) and body composition data were collected at baseline and 12-month follow-up. We used multivariable linear regression to compare BP changes in PWH and HIV-uninfected adults, and the relationship between changes in body composition and changes in BP.

RESULTS:

BP data were available for 640 PWH and 299 HIV-uninfected adults. Sixty-four percent were women and the mean age was 38 years. In PWH, systolic BP (SBP) increased (114-118) whereas SBP decreased (125-123) in HIV-uninfected participants. Fat mass increased by 1.6 kg on average in PWH and was strongly associated with the change in BP (P < 0.001). The greater increase in SBP in PWH was partly explained by the lower baseline SBP but PWH still experienced a 2.2 (95% CI 0.3-4.2) greater increase in SBP after adjustment. Weight gain partially mediated the relationship between HIV and SBP increase in PWH; a 1-kg increase in fat mass accounted for 0.8 (95% CI 0.6-1.1) increase in SBP.

CONCLUSIONS:

Weight and fat mass increase rapidly in PWH during the first 12 months of antiretroviral therapy and contribute to a rapid increase in SBP. Interventions to prevent excessive increase in fat mass are needed for PWH.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País como asunto: Africa Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones por VIH Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País como asunto: Africa Idioma: En Año: 2022 Tipo del documento: Article