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A comparison of methods to harmonize cortical thickness measurements across scanners and sites.
Sun, Delin; Rakesh, Gopalkumar; Haswell, Courtney C; Logue, Mark; Baird, C Lexi; O'Leary, Erin N; Cotton, Andrew S; Xie, Hong; Tamburrino, Marijo; Chen, Tian; Dennis, Emily L; Jahanshad, Neda; Salminen, Lauren E; Thomopoulos, Sophia I; Rashid, Faisal; Ching, Christopher R K; Koch, Saskia B J; Frijling, Jessie L; Nawijn, Laura; van Zuiden, Mirjam; Zhu, Xi; Suarez-Jimenez, Benjamin; Sierk, Anika; Walter, Henrik; Manthey, Antje; Stevens, Jennifer S; Fani, Negar; van Rooij, Sanne J H; Stein, Murray; Bomyea, Jessica; Koerte, Inga K; Choi, Kyle; van der Werff, Steven J A; Vermeiren, Robert R J M; Herzog, Julia; Lebois, Lauren A M; Baker, Justin T; Olson, Elizabeth A; Straube, Thomas; Korgaonkar, Mayuresh S; Andrew, Elpiniki; Zhu, Ye; Li, Gen; Ipser, Jonathan; Hudson, Anna R; Peverill, Matthew; Sambrook, Kelly; Gordon, Evan; Baugh, Lee; Forster, Gina.
  • Sun D; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs (VA) Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.; Department of Psychology, The Education University of Hong Kong, Hong Kong, China.
  • Rakesh G; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs (VA) Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
  • Haswell CC; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs (VA) Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
  • Logue M; National Center for PTSD, VA Boston Healthcare System, Boston, MA, USA.; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.; Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA.; Department of Biostatistics, Boston University School of Public Heal
  • Baird CL; Brain Imaging and Analysis Center, Duke University, Durham, NC, USA.; Department of Veteran Affairs (VA) Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA.
  • O'Leary EN; Department of Psychiatry, University of Toledo, Toledo, OH, USA.
  • Cotton AS; Department of Psychiatry, University of Toledo, Toledo, OH, USA.
  • Xie H; Department of Psychiatry, University of Toledo, Toledo, OH, USA.
  • Tamburrino M; Department of Psychiatry, University of Toledo, Toledo, OH, USA.
  • Chen T; Department of Psychiatry, University of Toledo, Toledo, OH, USA.; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA.
  • Dennis EL; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA.; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.; Department of Neurology, University of Utah, Salt Lake City, UT,
  • Jahanshad N; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
  • Salminen LE; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
  • Thomopoulos SI; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
  • Rashid F; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
  • Ching CRK; Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
  • Koch SBJ; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands.
  • Frijling JL; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Nawijn L; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Department of Psychiatry, Amsterdam University Medical Centers, VU University Medical Center, VU University, Amsterdam, The Netherlands.
  • van Zuiden M; Department of Psychiatry, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Zhu X; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.
  • Suarez-Jimenez B; Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY, USA.; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.; New York State Psychiatric Institute, New York, NY, USA.
  • Sierk A; University Medical Centre Charité, Berlin, Germany.
  • Walter H; University Medical Centre Charité, Berlin, Germany.
  • Manthey A; University Medical Centre Charité, Berlin, Germany.
  • Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Fani N; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • van Rooij SJH; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
  • Stein M; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
  • Bomyea J; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
  • Koerte IK; Psychiatry Neuroimaging Laboratory, Brigham & Women's Hospital, Boston, MA, USA.; Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany.
  • Choi K; Health Services Research Center, University of California, San Diego, La Jolla, CA, USA.
  • van der Werff SJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, Leiden, The Netherlands.
  • Vermeiren RRJM; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
  • Herzog J; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
  • Lebois LAM; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, USA.
  • Baker JT; Institute for Technology in Psychiatry, McLean Hospital, Harvard University, Belmont, MA, USA.
  • Olson EA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Center for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
  • Straube T; Institute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
  • Korgaonkar MS; Brain Dynamics Centre, Westmead Institute of Medical Research, University of Sydney, Westmead, NSW, Australia.
  • Andrew E; Department of Psychology, University of Sydney, Westmead, NSW, Australia.
  • Zhu Y; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Li G; Laboratory for Traumatic Stress Studies, Chinese Academy of Sciences Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
  • Ipser J; SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
  • Hudson AR; Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
  • Peverill M; Department of Psychology, University of Washington, Seattle, WA, USA.
  • Sambrook K; Department of Radiology, University of Washington, Seattle, WA, USA.
  • Gordon E; Department of Radiology, Washington University, St. Louis, MO, USA.
  • Baugh L; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Sioux Falls VA Health Care System, Sioux Falls, SD, USA.
  • Forster G; Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.; Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, USA.; Brain Health Research Centre, Department of Anatomy, University of Otago, Dunedin, New Zealan
Neuroimage ; 261: 119509, 2022 11 01.
Article en En | MEDLINE | ID: mdl-35917919
ABSTRACT
Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants' demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of four different harmonization methods on results obtained from analyses of cortical thickness data (1) linear mixed-effects model (LME) that models site-specific random intercepts (LMEINT), (2) LME that models both site-specific random intercepts and age-related random slopes (LMEINT+SLP), (3) ComBat, and (4) ComBat with a generalized additive model (ComBat-GAM). Our test case for comparing harmonization methods was cortical thickness data aggregated from 29 sites, which included 1,340 cases with posttraumatic stress disorder (PTSD) (6.2-81.8 years old) and 2,057 trauma-exposed controls without PTSD (6.3-85.2 years old). We found that, compared to the other data harmonization methods, data processed with ComBat-GAM was more sensitive to the detection of significant case-control differences (Χ2(3) = 63.704, p < 0.001) as well as case-control differences in age-related cortical thinning (Χ2(3) = 12.082, p = 0.007). Both ComBat and ComBat-GAM outperformed LME methods in detecting sex differences (Χ2(3) = 9.114, p = 0.028) in regional cortical thickness. ComBat-GAM also led to stronger estimates of age-related declines in cortical thickness (corrected p-values < 0.001), stronger estimates of case-related cortical thickness reduction (corrected p-values < 0.001), weaker estimates of age-related declines in cortical thickness in cases than controls (corrected p-values < 0.001), stronger estimates of cortical thickness reduction in females than males (corrected p-values < 0.001), and stronger estimates of cortical thickness reduction in females relative to males in cases than controls (corrected p-values < 0.001). Our results support the use of ComBat-GAM to minimize confounds and increase statistical power when harmonizing data with non-linear effects, and the use of either ComBat or ComBat-GAM for harmonizing data with linear effects.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Imagen por Resonancia Magnética Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Imagen por Resonancia Magnética Tipo de estudio: Guideline / Observational_studies / Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article