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A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes.
Bousbaine, Djenet; Fisch, Laura I; London, Mariya; Bhagchandani, Preksha; Rezende de Castro, Tiago B; Mimee, Mark; Olesen, Scott; Reis, Bernardo S; VanInsberghe, David; Bortolatto, Juliana; Poyet, Mathilde; Cheloha, Ross W; Sidney, John; Ling, Jingjing; Gupta, Aaron; Lu, Timothy K; Sette, Alessandro; Alm, Eric J; Moon, James J; Victora, Gabriel D; Mucida, Daniel; Ploegh, Hidde L; Bilate, Angelina M.
  • Bousbaine D; Microbiology Graduate Program, Massachussetts Institute of Technology (MIT), Cambridge, MA, USA.
  • Fisch LI; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • London M; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Bhagchandani P; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Rezende de Castro TB; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
  • Mimee M; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Olesen S; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Reis BS; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
  • VanInsberghe D; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
  • Bortolatto J; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Poyet M; Synthetic Biology Center, MIT, Cambridge, MA, USA.
  • Cheloha RW; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.
  • Sidney J; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Ling J; Department of Biological Engineering, MIT, Cambridge, MA, USA.
  • Gupta A; Laboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.
  • Lu TK; Microbiology Graduate Program, Massachussetts Institute of Technology (MIT), Cambridge, MA, USA.
  • Sette A; Department of Civil and Environmental Engineering, MIT, Cambridge, MA, USA.
  • Alm EJ; Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA.
  • Moon JJ; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA.
  • Victora GD; Department of Biological Engineering, MIT, Cambridge, MA, USA.
  • Mucida D; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Ploegh HL; Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, USA.
  • Bilate AM; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Science ; 377(6606): 660-666, 2022 08 05.
Article en En | MEDLINE | ID: mdl-35926021
ABSTRACT
The microbiome contributes to the development and maturation of the immune system. In response to commensal bacteria, intestinal CD4+ T lymphocytes differentiate into functional subtypes with regulatory or effector functions. The development of small intestine intraepithelial lymphocytes that coexpress CD4 and CD8αα homodimers (CD4IELs) depends on the microbiota. However, the identity of the microbial antigens recognized by CD4+ T cells that can differentiate into CD4IELs remains unknown. We identified ß-hexosaminidase, a conserved enzyme across commensals of the Bacteroidetes phylum, as a driver of CD4IEL differentiation. In a mouse model of colitis, ß-hexosaminidase-specific lymphocytes protected against intestinal inflammation. Thus, T cells of a single specificity can recognize a variety of abundant commensals and elicit a regulatory immune response at the intestinal mucosa.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Linfocitos T CD4-Positivos / Colitis / Bacteroidetes / Mucosa Intestinal Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Linfocitos T CD4-Positivos / Colitis / Bacteroidetes / Mucosa Intestinal Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article