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Palladium-Catalyzed Decarbonylative Cyanation of Carboxylic Acids with TMSCN.
Xu, Tianhao; Li, Wenhui; Zhang, Kang; Han, Yuhui; Liu, Long; Huang, Tianzeng; Li, Chunya; Tang, Zhi; Chen, Tieqiao.
  • Xu T; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Li W; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Zhang K; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Han Y; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Liu L; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Huang T; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Li C; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Tang Z; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
  • Chen T; Key Laboratory of the Ministry of Education for Advanced Materials in Tropical Island Resources, Hainan Provincial Key Laboratory of Fine Chemistry, Hainan Provincial Fine Chemical Engineering Research Center, Hainan University, Haikou 570228, China.
J Org Chem ; 87(17): 11871-11879, 2022 09 02.
Article en En | MEDLINE | ID: mdl-35951542
The direct decarbonylative cyanation of benzoic acids with TMSCN was achieved through palladium catalysis. By this strategy, a wide range of nitriles including those with functional groups was synthesized in good to high yields. Moreover, this reaction applied to modifying bioactive molecules such as adapalene, probenecid, telmisartan, and 3-methylflavone-8-carboxylic acid. These results demonstrate that this new reaction has potential synthetic value in organic synthesis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Paladio / Ácidos Carboxílicos Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Paladio / Ácidos Carboxílicos Idioma: En Año: 2022 Tipo del documento: Article