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A naturally arising broad and potent CD4-binding site antibody with low somatic mutation.
Barnes, Christopher O; Schoofs, Till; Gnanapragasam, Priyanthi N P; Golijanin, Jovana; Huey-Tubman, Kathryn E; Gruell, Henning; Schommers, Philipp; Suh-Toma, Nina; Lee, Yu Erica; Cetrulo Lorenzi, Julio C; Piechocka-Trocha, Alicja; Scheid, Johannes F; West, Anthony P; Walker, Bruce D; Seaman, Michael S; Klein, Florian; Nussenzweig, Michel C; Bjorkman, Pamela J.
  • Barnes CO; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Schoofs T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Gnanapragasam PNP; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
  • Golijanin J; German Center for Infection Research, partner site Bonn-Cologne, 50931 Cologne, Germany.
  • Huey-Tubman KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Gruell H; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Schommers P; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Suh-Toma N; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
  • Lee YE; German Center for Infection Research, partner site Bonn-Cologne, 50931 Cologne, Germany.
  • Cetrulo Lorenzi JC; Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
  • Piechocka-Trocha A; German Center for Infection Research, partner site Bonn-Cologne, 50931 Cologne, Germany.
  • Scheid JF; Department I of Internal Medicine, Faculty of Medicine and University Hospital of Cologne, University of Cologne, 50931 Cologne, Germany.
  • West AP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Walker BD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Seaman MS; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Klein F; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02129, USA.
  • Nussenzweig MC; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Sci Adv ; 8(32): eabp8155, 2022 Aug 12.
Article en En | MEDLINE | ID: mdl-35960796