Infective endocarditis in pregnant women without intravenous drug use: a multicentre retrospective case series.
J Antimicrob Chemother
; 77(10): 2701-2705, 2022 09 30.
Article
en En
| MEDLINE
| ID: mdl-35962570
ABSTRACT
OBJECTIVES:
To describe the clinical features and outcomes of infective endocarditis (IE) in pregnant women who do not inject drugs.METHODS:
A multinational retrospective study was performed at 14 hospitals. All definite IE episodes between January 2000 and April 2021 were included. The main outcomes were maternal mortality and pregnancy-related complications.RESULTS:
Twenty-five episodes of IE were included. Median age at IE diagnosis was 33.2â years (IQR 28.3-36.6) and median gestational age was 30â weeks (IQR 16-32). Thirteen (52%) patients had no previously known heart disease. Sixteen (64%) were native IE, 7 (28%) prosthetic and 2 (8%) cardiac implantable electronic device IE. The most common aetiologies were streptococci (nâ=â10, 40%), staphylococci (nâ=â5, 20%), HACEK group (nâ=â3, 12%) and Enterococcus faecalis (nâ=â3, 12%). Twenty (80%) patients presented at least one IE complication; the most common were heart failure (nâ=â13, 52%) and symptomatic embolism other than stroke (nâ=â4, 16%). Twenty-one (84%) patients had surgery indication and surgery was performed when indicated in 19 (90%). There was one maternal death and 16 (64%) patients presented pregnancy-related complications (11 patients ≥1 complication) 3 pregnancy losses, 9 urgent Caesarean sections, 2 emergency Caesarean sections, 1 fetal death, and 11 preterm births. Two patients presented a relapse during a median follow-up of 3.1â years (IQR 0.6-7.4).CONCLUSIONS:
Strict medical surveillance of pregnant women with IE is required and must involve a multidisciplinary team including obstetricians and neonatologists. Furthermore, the potential risk of IE during pregnancy should never be underestimated in women with previously known underlying heart disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Endocarditis
/
Endocarditis Bacteriana
Tipo de estudio:
Observational_studies
Límite:
Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Año:
2022
Tipo del documento:
Article