Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.

Saroja, Sivaprakasam R; Gorbachev, Kirill; Julia, Tcw; Goate, Alison M; Pereira, Ana C

Saroja, Sivaprakasam R; Gorbachev, Kirill; Julia, Tcw; Goate, Alison M; Pereira, Ana C.

Saroja SR; Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Gorbachev K; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Julia T; Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, NY 10029.
Goate AM; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Pereira AC; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Proc Natl Acad Sci U S A ; 119(34): e2108870119, 2022 08 23.

Article en En | MEDLINE | ID: mdl-35969759

Asunto(s)

Enfermedad de Alzheimer; Astrocitos; Glipicanos; Proteínas tau; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/metabolismo; Animales; Apolipoproteína E2/genética; Apolipoproteína E4/genética; Apolipoproteína E4/metabolismo; Astrocitos/metabolismo; Modelos Animales de Enfermedad; Glipicanos/metabolismo; Humanos; Ratones; Ratones Transgénicos; Fosforilación; Tauopatías/metabolismo; Tauopatías/fisiopatología; Proteínas tau/metabolismo

Palabras clave

APOE4; Alzheimer's disease; astrocytes; glypican-4; tau pathology

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Astrocitos / Proteínas tau / Glipicanos / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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