Saturation of the mitochondrial NADH shuttles drives aerobic glycolysis in proliferating cells.

Wang, Yahui; Stancliffe, Ethan; Fowle-Grider, Ronald; Wang, Rencheng; Wang, Cheng; Schwaiger-Haber, Michaela; Shriver, Leah P; Patti, Gary J

Wang, Yahui; Stancliffe, Ethan; Fowle-Grider, Ronald; Wang, Rencheng; Wang, Cheng; Schwaiger-Haber, Michaela; Shriver, Leah P; Patti, Gary J.

Wang Y; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Stancliffe E; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Fowle-Grider R; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Wang R; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Wang C; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Schwaiger-Haber M; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Shriver LP; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracing, Washington University in St. Louis, St. Louis, MO 63130, USA.
Patti GJ; Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO 63130, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO 63130, USA; Center for Metabolomics and Isotope Tracin

Mol Cell ; 82(17): 3270-3283.e9, 2022 09 01.

Article en En | MEDLINE | ID: mdl-35973426

Asunto(s)

Malatos; NAD; Ácido Aspártico/metabolismo; Glucosa/metabolismo; Glucólisis; Ácido Láctico; Malatos/metabolismo; NAD/metabolismo

Palabras clave

NADH shuttles; aerobic glycolysis; cancer metabolism; glycerol 3-phosphate shuttle; isotope-tracer analysis; malate-aspartate shuttle; metabolic flux; metabolomics; the Warburg effect

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