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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Shi, Diana D; Savani, Milan R; Levitt, Michael M; Wang, Adam C; Endress, Jennifer E; Bird, Cylaina E; Buehler, Joseph; Stopka, Sylwia A; Regan, Michael S; Lin, Yu-Fen; Puliyappadamba, Vinesh T; Gao, Wenhua; Khanal, Januka; Evans, Laura; Lee, Joyce H; Guo, Lei; Xiao, Yi; Xu, Min; Huang, Bofu; Jennings, Rebecca B; Bonal, Dennis M; Martin-Sandoval, Misty S; Dang, Tammie; Gattie, Lauren C; Cameron, Amy B; Lee, Sungwoo; Asara, John M; Kornblum, Harley I; Mak, Tak W; Looper, Ryan E; Nguyen, Quang-De; Signoretti, Sabina; Gradl, Stefan; Sutter, Andreas; Jeffers, Michael; Janzer, Andreas; Lehrman, Mark A; Zacharias, Lauren G; Mathews, Thomas P; Losman, Julie-Aurore; Richardson, Timothy E; Cahill, Daniel P; DeBerardinis, Ralph J; Ligon, Keith L; Xu, Lin; Ly, Peter; Agar, Nathalie Y R; Abdullah, Kalil G; Harris, Isaac S; Kaelin, William G.
  • Shi DD; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA 02215, USA; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Savani MR; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Levitt MM; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Wang AC; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Endress JE; Ludwig Cancer Center, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Bird CE; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
  • Buehler J; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Stopka SA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lin YF; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Puliyappadamba VT; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Gao W; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Khanal J; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Evans L; Bayer HealthCare Pharmaceuticals, Inc., Cambridge, MA 02142, USA.
  • Lee JH; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Guo L; Quantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Xiao Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Xu M; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Huang B; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Jennings RB; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Bonal DM; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.
  • Martin-Sandoval MS; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Dang T; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Gattie LC; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
  • Cameron AB; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.
  • Lee S; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea.
  • Asara JM; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Kornblum HI; Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Behavioral Sciences, and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA.
  • Mak TW; The Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON M5G 2M9, Canada; The Princess Margaret Cancer Centre and Ontario Cancer Institute, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto
  • Looper RE; Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
  • Nguyen QD; Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, MA 02210, USA.
  • Signoretti S; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Gradl S; Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany.
  • Sutter A; Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany.
  • Jeffers M; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ 07981, USA.
  • Janzer A; Bayer AG, Muellerstrasse 178, 13353 Berlin, Germany.
  • Lehrman MA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Zacharias LG; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Mathews TP; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Losman JA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
  • Richardson TE; Department of Pathology, Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Cahill DP; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • DeBerardinis RJ; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Compr
  • Ligon KL; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pathology, Children's Hospital Boston, Boston, MA 02115, USA.
  • Xu L; Quantitative Biomedical Research Center, Department of Population & Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
  • Ly P; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Agar NYR; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, M
  • Abdullah KG; Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Hillman Comprehensive Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA.
  • Harris IS; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.
  • Kaelin WG; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: william_kaelin@dfci.harvard.edu.
Cancer Cell ; 40(9): 939-956.e16, 2022 09 12.
Article en En | MEDLINE | ID: mdl-35985343
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Leucemia / Glioma Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Leucemia / Glioma Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article