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PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.
Malik, Asad U; Karapetsas, Athanasios; Nirujogi, Raja S; Chatterjee, Deep; Phung, Toan K; Wightman, Melanie; Gourlay, Robert; Morrice, Nick; Mathea, Sebastian; Knapp, Stefan; Alessi, Dario R.
  • Malik AU; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Karapetsas A; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A.
  • Nirujogi RS; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Chatterjee D; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Phung TK; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A.
  • Wightman M; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A.
  • Gourlay R; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences and Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.
  • Morrice N; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Mathea S; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, U.S.A.
  • Knapp S; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
  • Alessi DR; Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.
Biochem J ; 479(18): 1941-1965, 2022 09 30.
Article en En | MEDLINE | ID: mdl-36040231

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / GTP Fosfohidrolasas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Serina-Treonina Quinasas / GTP Fosfohidrolasas Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article