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Accurate de novo design of membrane-traversing macrocycles.
Bhardwaj, Gaurav; O'Connor, Jacob; Rettie, Stephen; Huang, Yen-Hua; Ramelot, Theresa A; Mulligan, Vikram Khipple; Alpkilic, Gizem Gokce; Palmer, Jonathan; Bera, Asim K; Bick, Matthew J; Di Piazza, Maddalena; Li, Xinting; Hosseinzadeh, Parisa; Craven, Timothy W; Tejero, Roberto; Lauko, Anna; Choi, Ryan; Glynn, Calina; Dong, Linlin; Griffin, Robert; van Voorhis, Wesley C; Rodriguez, Jose; Stewart, Lance; Montelione, Gaetano T; Craik, David; Baker, David.
  • Bhardwaj G; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA; Biological Physics, Structure and Design program, University of Washington, Seattle, WA 98195, USA. Electronic address: gauravb@uw.edu.
  • O'Connor J; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Biological Physics, Structure and Design program, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Rettie S; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Molecular Cell and Biology program, University of Washington, Seattle, WA 98195, USA.
  • Huang YH; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Ramelot TA; Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  • Mulligan VK; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Alpkilic GG; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA; Molecular Engineering and Sciences Program, University of Washington, Seattle, WA 98195, USA.
  • Palmer J; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Bera AK; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Bick MJ; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Di Piazza M; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Medicinal Chemistry, University of Washington, Seattle, WA 98195, USA.
  • Li X; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Hosseinzadeh P; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Craven TW; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Tejero R; Departamento de Quίmica Fίsica, Universidad de Valencia, Avenida Dr. Moliner 50, Burjassot, 46100 Valencia, Spain.
  • Lauko A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Biological Physics, Structure and Design program, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Choi R; Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA, USA.
  • Glynn C; Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
  • Dong L; Takeda Pharmaceuticals Inc., Cambridge, MA, USA.
  • Griffin R; Takeda Pharmaceuticals Inc., Cambridge, MA, USA.
  • van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Disease, University of Washington, Seattle, WA, USA.
  • Rodriguez J; Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA.
  • Stewart L; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
  • Montelione GT; Department of Chemistry and Chemical Biology and Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
  • Craik D; Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Baker D; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address: dabaker@uw.edu.
Cell ; 185(19): 3520-3532.e26, 2022 09 15.
Article en En | MEDLINE | ID: mdl-36041435
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Amidas Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Péptidos / Amidas Tipo de estudio: Prognostic_studies Idioma: En Año: 2022 Tipo del documento: Article