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Virtual screening for small-molecule pathway regulators by image-profile matching.
Rohban, Mohammad H; Fuller, Ashley M; Tan, Ceryl; Goldstein, Jonathan T; Syangtan, Deepsing; Gutnick, Amos; DeVine, Ann; Nijsure, Madhura P; Rigby, Megan; Sacher, Joshua R; Corsello, Steven M; Peppler, Grace B; Bogaczynska, Marta; Boghossian, Andrew; Ciotti, Gabrielle E; Hands, Allison T; Mekareeya, Aroonroj; Doan, Minh; Gale, Jennifer P; Derynck, Rik; Turbyville, Thomas; Boerckel, Joel D; Singh, Shantanu; Kiessling, Laura L; Schwarz, Thomas L; Varelas, Xaralabos; Wagner, Florence F; Kafri, Ran; Eisinger-Mathason, T S Karin; Carpenter, Anne E.
  • Rohban MH; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Fuller AM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Tan C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Syangtan D; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gutnick A; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
  • DeVine A; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Nijsure MP; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Rigby M; Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Sacher JR; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Corsello SM; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Peppler GB; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
  • Bogaczynska M; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Boghossian A; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Ciotti GE; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Hands AT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Mekareeya A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Doan M; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gale JP; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Derynck R; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Turbyville T; Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Boerckel JD; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
  • Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Schwarz TL; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
  • Varelas X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wagner FF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kafri R; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Eisinger-Mathason TSK; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: karineis@pennmedicine.upenn.edu.
  • Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org.
Cell Syst ; 13(9): 724-736.e9, 2022 09 21.
Article en En | MEDLINE | ID: mdl-36057257
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estudios Prospectivos Tipo de estudio: Diagnostic_studies / Observational_studies / Screening_studies Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Estudios Prospectivos Tipo de estudio: Diagnostic_studies / Observational_studies / Screening_studies Idioma: En Año: 2022 Tipo del documento: Article