Intranasal administration of ß-1, 3-galactosyltransferase 2 confers neuroprotection against ischemic stroke by likely inhibiting oxidative stress and NLRP3 inflammasome activation.

Guo, Xun; Zhang, Yang; Liu, Chang; Ren, Lili; Gao, Shuang; Bi, Jing; Liang, Jia; Wang, Peng

Guo, Xun; Zhang, Yang; Liu, Chang; Ren, Lili; Gao, Shuang; Bi, Jing; Liang, Jia; Wang, Peng.

Guo X; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Zhang Y; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Liu C; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Ren L; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Gao S; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Bi J; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.
Liang J; Institute of Life Science, Jinzhou Medical University, Jinzhou, China.
Wang P; Department of Neurobiology and Key Laboratory of Neurodegenerative Diseases of Liaoning Province, Jinzhou Medical University, Jinzhou, China.

FASEB J ; 36(10): e22542, 2022 10.

Article en En | MEDLINE | ID: mdl-36094000

Asunto(s)

Isquemia Encefálica; Accidente Cerebrovascular Isquémico; Fármacos Neuroprotectores; Daño por Reperfusión; Administración Intranasal; Animales; Isquemia Encefálica/tratamiento farmacológico; Isquemia Encefálica/metabolismo; Modelos Animales de Enfermedad; Galactosiltransferasas/metabolismo; Galactosiltransferasas/farmacología; Galactosiltransferasas/uso terapéutico; Humanos; Infarto de la Arteria Cerebral Media/metabolismo; Inflamasomas/metabolismo; Ratones; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Neuroprotección; Fármacos Neuroprotectores/farmacología; Fármacos Neuroprotectores/uso terapéutico; Estrés Oxidativo; ARN Interferente Pequeño/metabolismo; Ratas; Ratas Sprague-Dawley; Daño por Reperfusión/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

B3galt2; NLRP3 inflammasome; TGF-ß1; ischemic stroke; oxidative stress

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Daño por Reperfusión / Isquemia Encefálica / Fármacos Neuroprotectores / Accidente Cerebrovascular Isquémico Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article

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