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Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.
Fasano, Alfonso; Martinez-Valbuena, Ivan; Azevedo, Paula; da Silva, Carolina Candeias; Algarni, Musleh; Vasilevskaya, Anna; Anastassiadis, Chloe; Taghdiri, Foad; Kongkham, Paul; Radovanovic, Ivan; Zadeh, Gelareh; Lang, Anthony E; Tang-Wai, David F; Kovacs, Gabor G; Tartaglia, Maria Carmela.
  • Fasano A; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Martinez-Valbuena I; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Azevedo P; Krembil Brain Institute, Toronto, Ontario, Canada.
  • da Silva CC; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, Ontario, Canada.
  • Algarni M; Howard Cohen Normal Pressure Hydrocephalus Program, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Vasilevskaya A; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
  • Anastassiadis C; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Taghdiri F; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Kongkham P; Neurosciences Center, King Abdullah Medical City, Mecca, Saudi Arabia.
  • Radovanovic I; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Zadeh G; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Lang AE; Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.
  • Tang-Wai DF; Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
  • Kovacs GG; Neurosciences Center, King Abdullah Medical City, Mecca, Saudi Arabia.
  • Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Ann Neurol ; 92(6): 985-991, 2022 12.
Article en En | MEDLINE | ID: mdl-36094107
ABSTRACT
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92985-991.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sinucleinopatías / Hidrocéfalo Normotenso Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sinucleinopatías / Hidrocéfalo Normotenso Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article