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Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Spring, Jessica; Khan, Aly A; Lara, Sophie; O'Grady, Kelly; Wilks, Jessica; Gurbuxani, Sandeep; Erickson, Steven; Fischbach, Michael; Jacobson, Amy; Chervonsky, Alexander; Golovkina, Tatyana.
  • Spring J; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.
  • Khan AA; Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
  • Lara S; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
  • O'Grady K; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
  • Wilks J; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA.
  • Gurbuxani S; Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
  • Erickson S; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.
  • Fischbach M; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Jacobson A; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Chervonsky A; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Pathology, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA.
  • Golovkina T; Committee on Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Committee on Immunology, University of Chicago, Chicago, IL 60637, USA; Committee on Genetics, Genomics and System Biology, University of Chicago, Chic
Cell Rep ; 40(11): 111341, 2022 09 13.
Article en En | MEDLINE | ID: mdl-36103821
ABSTRACT
The influence of the microbiota on viral transmission and replication is well appreciated. However, its impact on retroviral pathogenesis outside of transmission/replication control remains unknown. Using murine leukemia virus (MuLV), we found that some commensal bacteria promoted the development of leukemia induced by this retrovirus. The promotion of leukemia development by commensals is due to suppression of the adaptive immune response through upregulation of several negative regulators of immunity. These negative regulators include Serpinb9b and Rnf128, which are associated with a poor prognosis of some spontaneous human cancers. Upregulation of Serpinb9b is mediated by sensing of bacteria by the NOD1/NOD2/RIPK2 pathway. This work describes a mechanism by which the microbiota enhances tumorigenesis within gut-distant organs and points at potential targets for cancer therapy.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retroviridae / Leucemia Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Retroviridae / Leucemia Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article