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Clinical presentation, biochemical profile, and HLA haplotype frequency of celiac disease among adults in Northwest China.
Shi, Tian; Feng, Yan; Li, Zi Qiong; Lu, Jia Jie; Abudurexiti, Adilai; Maimaitireyimu, Ayinuer; Hu, Jia Li; Wang, Man; Zhou, Hong Bo; Abudureyimu, Aini; Mei, Xin; Guo, Xin Wen; Liu, Wei Dong; Gao, Feng.
  • Shi T; Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Feng Y; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Li ZQ; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Lu JJ; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Abudurexiti A; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Maimaitireyimu A; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Hu JL; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Wang M; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Zhou HB; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Abudureyimu A; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Mei X; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Guo XW; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Liu WD; Xinjiang Clinical Research Center for Digestive Diseases, Urumqi, Xinjiang Uygur Autonomous Region, China.
  • Gao F; Department of Gastroenterology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China.
J Dig Dis ; 23(8-9): 506-515, 2022 Aug.
Article en En | MEDLINE | ID: mdl-36183167
ABSTRACT

OBJECTIVE:

To evaluate the clinical characteristics, biochemical parameters and the distribution of HLA-DQ genotypes among adult patients with celiac disease (CD) in Northwest China.

METHODS:

This cross-sectional study retrospectively collected clinical, biochemical, and HLA-DQ genotype of patients with CD from a tertiary hospital in Xinjiang Uygur Autonomous Region, China between March 2016 and December 2021. Small intestinal biopsy and serum-specific antibodies were used to diagnose CD.

RESULTS:

Of the 102 CD patients, 63.7% were women (female male = 1.761), and the mean age was 47.3 ± 14.7 years at diagnosis. Common gastrointestinal symptoms included abdominal pain (50.0%), diarrhea (39.2%), and abdominal distension (24.5%). While common extraintestinal manifestations were anemia (48.0%), osteopenia or osteoporosis (36.3%), and fatigue (35.3%). Approximately 34.3% of patients with CD had comorbidities, with the most common being thyroid diseases (18.6%). Biochemical profiles showed lower hemoglobin, higher platelet count, and 25-hydroxyvitamin D (25[OH]D) deficiency. HLA-DQ2/DQ8 was detected among all 53 patients who underwent genotype testing; the frequency of the HLA-DQ2.5, DQ2.2, and DQ8 haplotypes was 71.7%, 24.5%, and 3.8%, respectively.

CONCLUSIONS:

CD was more common among women. Clinical manifestations include primarily gastrointestinal symptoms, but extraintestinal manifestations were not uncommon. Lower hemoglobin level, higher platelet count, and 25[OH]D deficiency are the main biochemical manifestations. The HLA-DQ2.5 and DQ2.2 haplotypes are the most common genotypes in CD.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad Celíaca Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Año: 2022 Tipo del documento: Article