Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators.

Farmer, James P; Mistry, Shailesh N; Laughton, Charles A; Holliday, Nicholas D

Farmer, James P; Mistry, Shailesh N; Laughton, Charles A; Holliday, Nicholas D.

Farmer JP; School of Life Sciences, The Medical School, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Mistry SN; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, Nottingham, UK.
Laughton CA; School of Pharmacy, University of Nottingham, Nottingham, UK.
Holliday ND; School of Pharmacy, University of Nottingham, Nottingham, UK.

FASEB J ; 36(11): e22576, 2022 11.

Article en En | MEDLINE | ID: mdl-36183332

Asunto(s)

Técnicas Biosensibles; Receptores de Interleucina-8B; Regulación Alostérica; Sitio Alostérico; Aminoácidos; Proteínas de Unión al GTP/metabolismo; Ligandos; Péptidos/metabolismo; Péptidos/farmacología; Receptores Acoplados a Proteínas G/metabolismo; Receptores de Interleucina-8B/metabolismo

Palabras clave

Allosteric modulators; Biosensors; CXCR2; GPCRs; Prostanoid receptor EP2; ß2-Adrenoceptor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Receptores de Interleucina-8B Idioma: En Año: 2022 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Receptores de Interleucina-8B Idioma: En Año: 2022 Tipo del documento: Article