Screening potential anaphylactoid components in vinpocetine injection using a high expression Mas-related G-protein-coupled receptor X2 cell membrane chromatography.

Lu, Jiayu; Jia, Xin; Wang, Changhe; He, Huaizhen

Lu, Jiayu; Jia, Xin; Wang, Changhe; He, Huaizhen.

Lu J; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jia X; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Wang C; Shaanxi Institute for Food and Drug Control, Xi'an, Shaanxi, China.
He H; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China.

J Appl Toxicol ; 43(4): 508-516, 2023 04.

Article en En | MEDLINE | ID: mdl-36199206

Asunto(s)

Anafilaxia; Vincamina; Humanos; Animales; Ratones; Células HEK293; Anafilaxia/inducido químicamente; Vincamina/metabolismo; Vincamina/uso terapéutico; Excipientes; Receptores Acoplados a Proteínas G/metabolismo; Membrana Celular/metabolismo; Cromatografía; Mastocitos/metabolismo; Degranulación de la Célula; Proteínas del Tejido Nervioso/metabolismo; Receptores de Neuropéptido/metabolismo; Receptores de Neuropéptido/uso terapéutico

Palabras clave

Mas-related G-protein-coupled receptor X2 (MRGPRX2); cell membrane chromatography (CMC); impurity C; pseudo-allergic reaction; vinpocetine injection

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Vincamina / Anafilaxia Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article

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