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Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2.
Pymm, Phillip; Redmond, Samuel J; Dolezal, Olan; Mordant, Francesca; Lopez, Ester; Cooney, James P; Davidson, Kathryn C; Haycroft, Ebene R; Tan, Chee Wah; Seneviratna, Rebecca; Grimley, Samantha L; Purcell, Damian F J; Kent, Stephen J; Wheatley, Adam K; Wang, Lin-Fa; Leis, Andrew; Glukhova, Alisa; Pellegrini, Marc; Chung, Amy W; Subbarao, Kanta; Uldrich, Adam P; Tham, Wai-Hong; Godfrey, Dale I; Gherardin, Nicholas A.
  • Pymm P; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
  • Redmond SJ; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Dolezal O; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Mordant F; Commonwealth Scientific and Industrial Research Organisation (CSIRO) Biomedical Program, Clayton, VIC 3168, Australia.
  • Lopez E; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Cooney JP; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Davidson KC; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
  • Haycroft ER; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Tan CW; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
  • Seneviratna R; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Grimley SL; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Purcell DFJ; Programme in Emerging Infectious Diseases, Duke NUS Medical School, Singapore 169857, Singapore.
  • Kent SJ; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Wheatley AK; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Wang LF; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Leis A; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Glukhova A; Australian Research Council Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne VIC 3010, Australia.
  • Pellegrini M; Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, VIC 3000, Australia.
  • Chung AW; Programme in Emerging Infectious Diseases, Duke NUS Medical School, Singapore 169857, Singapore.
  • Subbarao K; Programme in Emerging Infectious Diseases, Duke NUS Medical School, Singapore 169857, Singapore.
  • Uldrich AP; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
  • Tham WH; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
  • Godfrey DI; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3010, Australia.
  • Gherardin NA; Drug Discovery Biology, Monash Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville 3052 VIC, Australia.
iScience ; 25(11): 105259, 2022 Nov 18.
Article en En | MEDLINE | ID: mdl-36213007