Molecular and genetic mechanisms in brain arteriovenous malformations: new insights and future perspectives.
Neurosurg Rev
; 45(6): 3573-3593, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36219361
ABSTRACT
Brain arteriovenous malformations (bAVMs) are rare vascular lesions made of shunts between cerebral arteries and veins without the interposition of a capillary bed. The majority of bAVMs are asymptomatic, but some may be revealed by seizures and potentially life-threatening brain hemorrhage. The management of unruptured bAVMs remains a matter of debate. Significant progress in the understanding of their pathogenesis has been made during the last decade, particularly using genome sequencing and biomolecular analysis. Herein, we comprehensively review the recent molecular and genetic advances in the study of bAVMs that not only allow a better understanding of the genesis and growth of bAVMs, but also open new insights in medical treatment perspectives.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Malformaciones Arteriovenosas Intracraneales
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article