[Dasatinib-induced follicular lymphoid hyperplasia, an entity to know]. / Hyperplasie lymphoïde folliculaire induite par la prise de dasatinib, une entité à connaître.
Ann Pathol
; 43(1): 45-51, 2023 Jan.
Article
en Fr
| MEDLINE
| ID: mdl-36266200
ABSTRACT
Follicular lymphoid hyperplasia induced by dasatinib is an entity recently described. It is sometimes difficult to rule out the diagnostic of small B-cell lymphoma. Usually, the node is swollen, with follicular architecture conserved, composed by germinal centers with variable size and shape, with a hight number of mitoses and tingible bodies macrophages inside. Follicular lymphoid hyperplasia is isolated or associated with multiple reactive patterns. The immunohistochemical profil of germinal centers is CD20+, CD10+, BCL6+, BCL2-. Swollen node disappears in a short time after dasatinib discontinuation. Clinicians and pathologists need to be aware of this entity, so as not to avoid mistakenly suspect lymphoma when lymphadenopathy occurs in a patient with chronic myeloid leukemia treated with dasatinib.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucemia Linfocítica Crónica de Células B
/
Linfoma Folicular
/
Linfadenopatía
Límite:
Humans
Idioma:
Fr
Año:
2023
Tipo del documento:
Article