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A bovine antibody possessing an ultralong complementarity-determining region CDRH3 targets a highly conserved epitope in sarbecovirus spike proteins.
Burke, Matthew J; Scott, James N F; Minshull, Thomas C; Gao, Zeqian; Manfield, Iain; Savic, Sinisa; Stockley, Peter G; Calabrese, Antonio N; Boyes, Joan.
  • Burke MJ; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Scott JNF; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Minshull TC; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Gao Z; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Manfield I; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Savic S; National Institute for Health Research, Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, Wellcome Trust Brenner Building, St James's University Hospital, Leeds, United Kingdom.
  • Stockley PG; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Calabrese AN; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom; Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
  • Boyes J; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom. Electronic address: j.m.boyes@leeds.ac.uk.
J Biol Chem ; 298(12): 102624, 2022 12.
Article en En | MEDLINE | ID: mdl-36272646
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regiones Determinantes de Complementariedad / Glicoproteína de la Espiga del Coronavirus / Anticuerpos Antivirales Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regiones Determinantes de Complementariedad / Glicoproteína de la Espiga del Coronavirus / Anticuerpos Antivirales Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article