Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways.

Zhao, Hongyi; Wang, Xi; Tang, Yanhong; Zhao, Qingyan; Huang, Congxin

Inhibition of intermittent calcium-activated potassium channel (SK4) attenuates Ang II-induced hypertrophy of human-induced stem cell-derived cardiomyocytes via targeting Ras-Raf-MEK1/2-ERK1/2 and CN-NFAT signaling pathways.

Zhao, Hongyi; Wang, Xi; Tang, Yanhong; Zhao, Qingyan; Huang, Congxin.

Zhao H; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P. R. China.
Wang X; Cardiovascular Research Institute, Wuhan University, Wuhan, P. R. China.
Tang Y; Hubei Key Laboratory of Cardiology, Wuhan, P. R. China.
Zhao Q; Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, P. R. China.
Huang C; Cardiovascular Research Institute, Wuhan University, Wuhan, P. R. China.

Cell Biol Int ; 47(2): 480-491, 2023 Feb.

Article en En | MEDLINE | ID: mdl-36273427

Asunto(s)

Angiotensina II; Miocitos Cardíacos; Humanos; Miocitos Cardíacos/metabolismo; Angiotensina II/farmacología; Angiotensina II/metabolismo; Factores de Transcripción NFATC/metabolismo; Sistema de Señalización de MAP Quinasas; MAP Quinasa Quinasa 1/metabolismo; Transducción de Señal; Cardiomegalia/metabolismo; ARN Mensajero/metabolismo; Células Madre/metabolismo

Palabras clave

ERK1/2; SK4; cardiac hypertrophy; hiPSC-CMs

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Angiotensina II / Miocitos Cardíacos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Angiotensina II / Miocitos Cardíacos Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article