Association between Pediatric Adenovirus Infection and Type 1 Diabetes.
Children (Basel)
; 9(10)2022 Sep 29.
Article
en En
| MEDLINE
| ID: mdl-36291430
ABSTRACT
BACKGROUND:
Viruses are among the inducers of type 1 diabetes (T1D) as they are implicated in the initiation of ß-cell destruction. This study aimed to explore the link between adenoviruses' infection, inflammatory biomarkers, and the development of T1D.METHODS:
The study population included 80 children with T1D and 40 healthy controls (2-16 years old). The T1D group was further clustered into two groups according to time of T1D diagnosis a group of children who were diagnosed during the first year of life and a second group who were diagnosed after the first year of life. Adenovirus DNA, anti-adenovirus IgG, cytokines, and lipid profiles were screened in the different groups. The results were statistically assessed using one-way analysis of variance (ANOVA) and LSD t-test.RESULTS:
Positive adenovirus PCR was detected in 2.5% and 20% of normal and T1D children, respectively. Moreover, the positive PCR results for adenovirus were found significantly higher in the T1D group, who were diagnosed during the first year of life (33.4%), in comparison to those diagnosed after the first year of life (12%). Anti-adenoviruses IgG was found in 12.5% and 40% of healthy controls and diabetic children, respectively. Seropositive results were found to be higher in newly diagnosed children (46.7%) in comparison to those previously diagnosed with T1D (36%). Body mass index (BMI), IFN-γ, IL-15, adiponectin, lipid profile, and microalbuminuria were significantly increased in T1D adenoviruses-positive children compared to children who were negative for adenoviruses.CONCLUSIONS:
Adenovirus infection could be among the contributing risk factors and may play a role in the induction of T1D in children.
Texto completo:
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Banco de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Año:
2022
Tipo del documento:
Article