Palmitic acid induces nDNA release to cytosol and promotes microglial M1 polarization via cGAS-STING signaling pathway.

Deng, Yuping; Yi, Xiaoqing; Gong, Yuxiang; Zhou, Liyan; Xie, Dongxue; Wang, Jufen; Liu, Zhilin; Zhang, Yinhao; Wu, Wenhe

Deng, Yuping; Yi, Xiaoqing; Gong, Yuxiang; Zhou, Liyan; Xie, Dongxue; Wang, Jufen; Liu, Zhilin; Zhang, Yinhao; Wu, Wenhe.

Deng Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yi X; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Gong Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhou L; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Xie D; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wang J; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Liu Z; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhang Y; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wu W; Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: wuwenhe2000@163.com.

Biochim Biophys Acta Mol Cell Res ; 1870(1): 119385, 2023 01.

Article en En | MEDLINE | ID: mdl-36302463

Asunto(s)

Microglía; Ácido Palmítico; Microglía/metabolismo; Ácido Palmítico/farmacología; Ácido Palmítico/metabolismo; Células Endoteliales/metabolismo; Citosol/metabolismo; Transducción de Señal; Nucleotidiltransferasas/genética; Nucleotidiltransferasas/metabolismo; ADN Mitocondrial/metabolismo

Palabras clave

Microglia; Nuclear DNA; Palmitic acid; cGAS

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microglía / Ácido Palmítico Idioma: En Año: 2023 Tipo del documento: Article

Texto completo

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PubMed Links

Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microglía / Ácido Palmítico Idioma: En Año: 2023 Tipo del documento: Article