National Monkeypox Surveillance, Central African Republic, 2001-2021.
Emerg Infect Dis
; 28(12): 2435-2445, 2022 12.
Article
en En
| MEDLINE
| ID: mdl-36328951
ABSTRACT
We analyzed monkeypox disease surveillance in Central African Republic (CAR) during 2001-2021. Surveillance data show 95 suspected outbreaks, 40 of which were confirmed as monkeypox, comprising 99 confirmed and 61 suspected monkeypox cases. After 2018, CAR's annual rate of confirmed outbreaks increased, and 65% of outbreaks occurred in 2 forested regions bordering the Democratic Republic of the Congo. The median patient age for confirmed cases was 15.5 years. The overall case-fatality ratio was 7.5% (12/160) for confirmed and suspected cases, 9.6% (8/83) for children <16 years of age. Decreasing cross-protective immunity from smallpox vaccination and recent ecologic alterations likely contribute to increased monkeypox outbreaks in Central Africa. High fatality rates associated with monkeypox virus clade I also are a local and international concern. Ongoing investigations of zoonotic sources and environmental changes that increase human exposure could inform practices to prevent monkeypox expansion into local communities and beyond endemic areas.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Mpox
Tipo de estudio:
Screening_studies
Límite:
Adolescent
/
Child
/
Humans
País como asunto:
Africa
Idioma:
En
Año:
2022
Tipo del documento:
Article