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Tecovirimat is effective against human monkeypox virus in vitro at nanomolar concentrations.
Frenois-Veyrat, Gaëlle; Gallardo, Franck; Gorgé, Olivier; Marcheteau, Elie; Ferraris, Olivier; Baidaliuk, Artem; Favier, Anne-Laure; Enfroy, Cécile; Holy, Xavier; Lourenco, Jérémy; Khoury, Rhéa; Nolent, Flora; Grosenbach, Douglas W; Hruby, Dennis E; Ferrier, Audrey; Iseni, Frédéric; Simon-Loriere, Etienne; Tournier, Jean-Nicolas.
  • Frenois-Veyrat G; Virology Unit, Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Gallardo F; Institut de Recherche Biomédicale des Armées, National Reference Center for Orthopoxviruses (CNR-LE Orthopoxvirus), Brétigny-sur-Orge, France.
  • Gorgé O; NeoVirTech, SAS, Toulouse, France.
  • Marcheteau E; Bacteriology Unit, Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Ferraris O; NeoVirTech, SAS, Toulouse, France.
  • Baidaliuk A; Virology Unit, Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Favier AL; Institut de Recherche Biomédicale des Armées, National Reference Center for Orthopoxviruses (CNR-LE Orthopoxvirus), Brétigny-sur-Orge, France.
  • Enfroy C; G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France.
  • Holy X; Imagery Unit, Platform and Technological Research Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Lourenco J; Imagery Unit, Platform and Technological Research Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Khoury R; Imagery Unit, Platform and Technological Research Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Nolent F; Maison Médicale Chemin Vert, Paris, France.
  • Grosenbach DW; Cerballiance, Paris, France.
  • Hruby DE; Bacteriology Unit, Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Ferrier A; SIGA Technologies, Inc., Corvallis, OR, USA.
  • Iseni F; SIGA Technologies, Inc., Corvallis, OR, USA.
  • Simon-Loriere E; Virology Unit, Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France.
  • Tournier JN; Institut de Recherche Biomédicale des Armées, National Reference Center for Orthopoxviruses (CNR-LE Orthopoxvirus), Brétigny-sur-Orge, France.
Nat Microbiol ; 7(12): 1951-1955, 2022 12.
Article en En | MEDLINE | ID: mdl-36344621
ABSTRACT
The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. We isolated and sequenced a virus from the first clinical MPXV case diagnosed in France (May 2022). We report that tecovirimat (ST-246), a US Food and Drug Administration approved drug, is efficacious against this isolate in vitro at nanomolar concentrations, whereas cidofovir is only effective at micromolar concentrations. Our results support the use of tecovirimat in ongoing human clinical trials.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Monkeypox virus / Mpox Límite: Humans País como asunto: America do norte Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Monkeypox virus / Mpox Límite: Humans País como asunto: America do norte Idioma: En Año: 2022 Tipo del documento: Article