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Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice.
Gul, Seref; Akyel, Yasemin Kubra; Gul, Zeynep Melis; Isin, Safak; Ozcan, Onur; Korkmaz, Tuba; Selvi, Saba; Danis, Ibrahim; Ipek, Ozgecan Savlug; Aygenli, Fatih; Taskin, Ali Cihan; Akarlar, Büsra Aytül; Ozlu, Nurhan; Ozturk, Nuri; Ozturk, Narin; Ünal, Durisehvar Özer; Guzel, Mustafa; Turkay, Metin; Okyar, Alper; Kavakli, Ibrahim Halil.
  • Gul S; Department of Chemical and Biological Engineering, Koc University, 34450, Sariyer-Istanbul, Turkey.
  • Akyel YK; Department of Biology, Biotechnology Division, Istanbul University, TR-34116, Beyazit-Istanbul, Turkey.
  • Gul ZM; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, TR-34116, Beyazit-Istanbul, Turkey.
  • Isin S; School of Medicine, Department of Medical Pharmacology, Istanbul Medipol University, Istanbul, Turkey.
  • Ozcan O; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey.
  • Korkmaz T; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey.
  • Selvi S; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey.
  • Danis I; Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Ipek OS; Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Aygenli F; Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul University, TR-34116, Beyazit-Istanbul, Turkey.
  • Taskin AC; Istanbul University Drug Research and Application Center (ILAM), TR-34116, Beyazit-Istanbul, Turkey.
  • Akarlar BA; Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Kavacik Campus, Kavacik-Beykoz/Istanbul, 34810, Turkey.
  • Ozlu N; Department of Chemistry, Graduate School of Natural and Applied Sciences, Yildiz Technical University, Besiktas/Istanbul, 34349, Turkey.
  • Ozturk N; Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Ozturk N; Animal Research Facility, Research Center for Translational Medicine, Koc University, Rumelifeneri yolu, 34450, Sariyer-Istanbul, Turkey.
  • Ünal DÖ; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey.
  • Guzel M; Department of Molecular Biology and Genetics, Koc University, Istanbul, Turkey.
  • Turkay M; Department of Molecular Biology and Genetics, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey.
  • Okyar A; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, TR-34116, Beyazit-Istanbul, Turkey.
  • Kavakli IH; Faculty of Pharmacy, Department of Analytical Chemistry, Istanbul University, TR-34116, Beyazit-Istanbul, Turkey.
Nat Commun ; 13(1): 6742, 2022 11 08.
Article en En | MEDLINE | ID: mdl-36347873
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Criptocromos / Relojes Circadianos Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Criptocromos / Relojes Circadianos Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article