Internal RNA 2'O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect.
Nucleic Acids Res
; 51(6): 2501-2515, 2023 04 11.
Article
en En
| MEDLINE
| ID: mdl-36354007
Despite highly effective antiretroviral therapies, the human immunodeficiency virus (HIV-1) remains a major public health threat. Its pathogenesis depends on its ability to establish a persistent infection in cells of the immune system. Our study highlights a new insight into how HIV-1 evades early restriction by the immune system. We showed that 2'O-methylation marks found inside HIV-1 RNA promote viral evasion from the antiviral action of the interferon-stimulated gene 20-kDa protein (ISG20), an innate immune restriction factor with a nuclease activity. By disrupting the level of 2'O-methylation of the HIV-1 genome, we demonstrated that ISG20 impairs the reverse transcription process of hypomethylated viruses, as a result of viral RNA decay.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN Viral
/
Infecciones por VIH
/
VIH-1
/
Exorribonucleasas
Límite:
Humans
Idioma:
En
Año:
2023
Tipo del documento:
Article