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Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate.
Hobson, Adrian D; McPherson, Michael J; Hayes, Martin E; Goess, Christian; Li, Xiang; Zhou, Jian; Wang, Zhongyuan; Yu, Yajie; Yang, Jindong; Sun, Liang; Zhang, Qiang; Qu, Pei; Yang, Shi; Hernandez, Axel; Bryant, Shaughn H; Mathieu, Suzanne L; Bischoff, Agnieszka K; Fitzgibbons, Julia; Santora, Ling C; Wang, Lu; Wang, Lu; Fettis, Margaret M; Li, Xiaofeng; Marvin, Christopher C; Wang, Zhi; Patel, Meena V; Schmidt, Diana L; Li, Tongmei; Randolph, John T; Henry, Rodger F; Graff, Candace; Tian, Yu; Aguirre, Ana L; Shrestha, Anurupa.
  • Hobson AD; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • McPherson MJ; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Hayes ME; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Goess C; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Li X; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Zhou J; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Wang Z; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Yu Y; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Yang J; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Sun L; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Zhang Q; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Qu P; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Yang S; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Hernandez A; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Bryant SH; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Mathieu SL; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Bischoff AK; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Fitzgibbons J; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Santora LC; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Fettis MM; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Li X; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China.
  • Marvin CC; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Wang Z; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Patel MV; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Schmidt DL; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Li T; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Randolph JT; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Henry RF; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Graff C; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Tian Y; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.
  • Aguirre AL; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
  • Shrestha A; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
J Med Chem ; 65(23): 15893-15934, 2022 12 08.
Article en En | MEDLINE | ID: mdl-36394224
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoconjugados / Glucocorticoides Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inmunoconjugados / Glucocorticoides Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2022 Tipo del documento: Article