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In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs.
Bechthold, Elena; Grey, Lucie; Diamant, Emil; Schmidt, Judith; Steigerwald, Ruben; Zhao, Fabao; Hansen, Kasper B; Bunch, Lennart; Clausen, Rasmus P; Wünsch, Bernhard.
  • Bechthold E; Westfälische Wilhelms-Universität Münster, GRK 2515, Chemical Biology of Ion Channels (Chembion), Corrensstraße 48, D-48149 Münster, Germany.
  • Grey L; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149 Münster, Germany.
  • Diamant E; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149 Münster, Germany.
  • Schmidt J; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
  • Steigerwald R; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149 Münster, Germany.
  • Zhao F; Westfälische Wilhelms-Universität Münster, GRK 2515, Chemical Biology of Ion Channels (Chembion), Corrensstraße 48, D-48149 Münster, Germany.
  • Hansen KB; Westfälische Wilhelms-Universität Münster, Institut für Pharmazeutische und Medizinische Chemie, Corrensstraße 48, D-48149 Münster, Germany.
  • Bunch L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44, Wenhua West Road, Lixia District, Ji'nan, Shandong, 250012, China.
  • Clausen RP; Center for Structural and Functional Neuroscience, Center for Biomolecular Structure and Dynamics, Division of Biological Sciences, University of Montana, 32 Campus Drive, Missoula, MT 59812, USA.
  • Wünsch B; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Biol Chem ; 404(4): 255-265, 2023 03 28.
Article en En | MEDLINE | ID: mdl-36427206
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Receptores de N-Metil-D-Aspartato Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Receptores de N-Metil-D-Aspartato Límite: Animals / Humans Idioma: En Año: 2023 Tipo del documento: Article