Construction of Spirocyclic Pyrrolo[1,2-a]quinoxalines via Palladium-Catalyzed Hydrogenative Coupling of Phenols and Nitroarenes.
J Org Chem
; 87(24): 16449-16457, 2022 12 16.
Article
en En
| MEDLINE
| ID: mdl-36455265
ABSTRACT
The replacement of fossil resources with biomass resources in the construction of N-heterocycles is rapidly attracting research interest. Herein, we report palladium-catalyzed selective hydrogenative coupling of nitroarenes and phenols based on a transfer hydrogenation strategy, allowing straightforward access to spirocyclic pyrrolo- and indolo-fused quinoxalines, a class of compounds found in numerous natural alkaloids. The synthetic protocol is characterized by a broad substrate scope and the utilization of biomass-derived reactants and commercially available catalysts. In such transformations, high-pressure and explosive hydrogen are not required. This report provides a new protocol for converting biomass-derived phenols into value-added nitrogen-containing chemicals.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Paladio
/
Quinoxalinas
Idioma:
En
Año:
2022
Tipo del documento:
Article