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Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer.
Tu, Jia-Li; Wu, Bi-Han; Wu, Heng-Bo; Wang, Jia-En; Zhang, Zi-Lin; Gao, Kun-Yu; Zhang, Lu-Xuan; Chen, Qin-Rui; Zhou, Ying-Chen; Tan, Jia-Heng; Huang, Zhi-Shu; Chen, Shuo-Bin.
  • Tu JL; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Wu BH; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Wu HB; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Wang JE; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Zhang ZL; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Gao KY; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Zhang LX; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Chen QR; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Zhou YC; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Tan JH; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Huang ZS; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Chen SB; School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: chenshb8@mail.sysu.edu.cn.
Eur J Med Chem ; 246: 114944, 2023 Jan 15.
Article en En | MEDLINE | ID: mdl-36459756
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de Bloom / Neoplasias Colorrectales Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de Bloom / Neoplasias Colorrectales Límite: Humans Idioma: En Año: 2023 Tipo del documento: Article