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Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
Craig, Robert A; Fox, Brian M; Hu, Cheng; Lexa, Katrina W; Osipov, Maksim; Thottumkara, Arun P; Larhammar, Martin; Miyamoto, Takashi; Rana, Anil; Kane, Lesley A; Yulyaningsih, Ernie; Solanoy, Hilda; Nguyen, Hoang; Chau, Roni; Earr, Timothy; Kajiwara, Yuji; Fleck, Daniel; Lucas, Anthony; Haddick, Patrick C G; Takahashi, Ryan H; Tong, Vincent; Wang, Jing; Canet, Mark J; Poda, Suresh B; Scearce-Levie, Kimberly; Srivastava, Ankita; Sweeney, Zachary K; Xu, Musheng; Zhang, Rui; He, Jianrong; Lei, Yanan; Zhuo, Zheng; de Vicente, Javier.
  • Craig RA; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Fox BM; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Hu C; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Lexa KW; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Osipov M; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Thottumkara AP; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Larhammar M; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Miyamoto T; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Rana A; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Kane LA; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Yulyaningsih E; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Solanoy H; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Nguyen H; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Chau R; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Earr T; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Kajiwara Y; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Fleck D; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Lucas A; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Haddick PCG; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Takahashi RH; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Tong V; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Wang J; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Canet MJ; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Poda SB; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Scearce-Levie K; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Srivastava A; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Sweeney ZK; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
  • Xu M; Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China.
  • Zhang R; Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China.
  • He J; Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China.
  • Lei Y; Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China.
  • Zhuo Z; Department of Chemistry, WuXi AppTec Co., Ltd., 168 Nanhai Road, 10th Avenue, Tianjin TEDA, Tianjin 300457, China.
  • de Vicente J; Denali Therapeutics Inc., 161 Oyster Point Blvd., South San Francisco, California 94080, United States.
J Med Chem ; 65(24): 16290-16312, 2022 12 22.
Article en En | MEDLINE | ID: mdl-36469401
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Esclerosis Amiotrófica Lateral Límite: Humans Idioma: En Año: 2022 Tipo del documento: Article