Prognostic role of pretreatment serum ferritin concentration in lung cancer patients: A meta-analysis.
World J Clin Cases
; 10(33): 12230-12239, 2022 Nov 26.
Article
en En
| MEDLINE
| ID: mdl-36483825
ABSTRACT
BACKGROUND:
The association between pretreatment serum ferritin concentration (SFC) and long-term survival in lung cancer remains unclear now.AIM:
To identify the prognostic value of pretreatment SFC in lung cancer patients based on current evidence.METHODS:
The PubMed, EMBASE and Web of Science databases were searched from inception to May 29, 2022 for relevant studies. The primary endpoint was overall survival (OS) and the hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were combined to assess the predictive role of pretreatment SFC for long-term survival of lung cancer patients. The data were then extracted and assessed on the basis of the Reference Citation Analysis (https//www.referencecitationanalysis.com/).RESULTS:
Twelve retrospective studies involving 1654 patients were analyzed. The results manifested that increased pretreatment SFC was associated with worse OS (HR = 1.09, 95%CI 1.03-1.15, P = 0.004). Subgroup analysis stratified by the country (China vs non-China) showed similar results. However, subgroup analysis stratified by tumor type revealed inconsistent results (lung cancer HR = 1.39, P = 0.008; small cell lung cancer HR = 1.99, P = 0.175; non-small cell lung cancer HR = 1.03, P = 0.281).CONCLUSION:
Pretreatment SFC might serve as a promising prognostic indicator in lung cancer patients and elevated pretreatment SFC predicts worse prognosis. However, more high-quality studies with big sample sizes are still needed to further verify its prognostic value in lung cancer.
Texto completo:
1
Banco de datos:
MEDLINE
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Año:
2022
Tipo del documento:
Article