Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer.
Int J Mol Sci
; 23(23)2022 Dec 04.
Article
en En
| MEDLINE
| ID: mdl-36499622
ABSTRACT
Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gastric cancer (GC). Accordingly, thermo-TRPs constitute a major pharmacological target, and the elucidation of the mechanisms underlying their response to physiological stimuli or drugs is key for notable advances in GC treatment. Therefore, this paper summarizes the existing literature about thermo-TRP protein expression changes that are linked to the incidence and progression of GC. The review also discusses the implication of such association to pathology and cell physiology and identifies potential thermo-TRP protein targets for diagnosis and treatment of GC.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Gástricas
/
Canales de Potencial de Receptor Transitorio
Límite:
Humans
Idioma:
En
Año:
2022
Tipo del documento:
Article