Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor.

Schoellkopf, Julian; Mueller, Thomas; Hippchen, Lena; Mueller, Teresa; Reuten, Raphael; Backofen, Rolf; Orth, Joachim; Schmidt, Gudula

Schoellkopf, Julian; Mueller, Thomas; Hippchen, Lena; Mueller, Teresa; Reuten, Raphael; Backofen, Rolf; Orth, Joachim; Schmidt, Gudula.

Schoellkopf J; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Mueller T; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Hippchen L; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Mueller T; Bioinformatics-Department of Computer Science, Albert-Ludwigs-University, Freiburg, Germany.
Reuten R; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.
Backofen R; Bioinformatics-Department of Computer Science, Albert-Ludwigs-University, Freiburg, Germany.
Orth J; Signalling Research Centres BIOSS and CIBSS, Albert-Ludwigs-University, Freiburg, Germany.
Schmidt G; Institute for Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany.

PLoS Pathog ; 18(12): e1010781, 2022 12.

Article en En | MEDLINE | ID: mdl-36516199

Asunto(s)

Proteínas de Unión al GTP Heterotriméricas; Pasteurella multocida; Animales; Porcinos; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/genética; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad/metabolismo; Proteínas Portadoras/metabolismo; Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas; Pasteurella multocida/genética; Pasteurella multocida/metabolismo; Proteínas de Unión al GTP Heterotriméricas/genética; Proteínas de Unión al GTP Heterotriméricas/metabolismo; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pasteurella multocida / Proteínas de Unión al GTP Heterotriméricas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2022 Tipo del documento: Article

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